Use of an embedded, micro-randomised trial to investigate non-compliance in telehealth trials

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Use of an embedded, micro-randomised trial to investigate non-compliance in telehealth trials

Telehealth interventions can provide remote monitoring of patients at home, through the use of electronic devices. For example, diabetics are asked to record regular blood glucose levels, and individuals with respiratory illnesses are asked to fill in electronic symptom questionnaires. As clinicians can monitor this ongoing data, they are aware of signs of poor health and can intervene to avoid...

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Estimating treatment effects in randomised controlled trials with non-compliance: a simulation study

OBJECTIVE Randomised controlled trials (RCTs) are often considered as the gold standard for assessing new health interventions. Patients are randomly assigned to receive an intervention or control. The effect of the intervention can be estimated by comparing outcomes between groups, whose prognostic factors are expected to balance by randomisation. However, patients' non-compliance with their a...

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A causal model for longitudinal randomised trials with time-dependent non-compliance

In the presence of non-compliance, conventional analysis by intention-to-treat provides an unbiased comparison of treatment policies but typically under-estimates treatment efficacy. With all-or-nothing compliance, efficacy may be specified as the complier-average causal effect (CACE), where compliers are those who receive intervention if and only if randomised to it. We extend the CACE approac...

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ژورنال

عنوان ژورنال: Trials

سال: 2015

ISSN: 1745-6215

DOI: 10.1186/1745-6215-16-s2-p222